Social Work for Older Adults with Dementia

Special Studies Experience, Summer 2016 -- Seoul, South Korea -- Partner Agencie(s): Social Work, Education and Social Development in Seoul of South Korea 2016http://deepblue.lib.umich.edu/bitstream/2027.42/134341/1/Poster_Kwon.pd

Review of \u3cem\u3eThe “Population Problem” in Pacific Asia\u3c/em\u3e by Stuart Gietel-Basten

Review of The “Population Problem” in Pacific Asia

Repeated Disasters and Chronic Environmental Changes Impede Generational Transmission of Indigenous Knowledge

Indigenous coastal communities are interdependent with the environment and families are vulnerable to the environmental changes that disrupt culture, continuity, and livelihood. The purpose of this study was to elucidate meaning from shared cultural perceptions of experiencing repeated disasters and other environmental changes among a United States Indigenous coastal community. This study is part of a larger community- engaged study and reports results from phenomological semi-structured in-depth qualitative interviews (n=19). Participants were enrolled tribal members with a strong ethnic identity and earned a majority of their income from subsistence activities. The results highlight that discrimination, which is part of the broader context of historical oppression, has set the stage for heightened vulnerability in Indigenous communities. Indigenous families are highly connected to their place and environment, yet environmental changes (e.g. repeated disasters, chronic land loss, and climate change) creates barriers for many elder participants pass on traditional knowledge and lifeways to their grandchildren and future generations. Indigenous peoples’ relationship with the land is spiritual, cultural, and place-specific. Interruption of Indigenous Peoples’ ability to interact with the land acculturation, lack of self-determination and discrimination are contemporary forms of trauma

[P3–496]: Informal Social Support, Stress, And Depressive Symptoms Among Spousal Dementia Caregivers Aged 60 Years And Over In The United States

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153228/1/alzjjalz2017061715.pd

RhI-catalyzed site-selective decarbonylative alkenylation and arylation of quinolones under chelation assistance

An efficient catalytic system for the C-2 selective C-H functionalization of 4-quinolones was developed by using a decarbonylative coupling strategy. The installation of an N-pyrimidyl group on the quinolone nitrogen atom redirected the coordination between the catalyst and the carbonyl group to promote direct C-H functionalization at the 2-position of 4-quinolones. In addition, the present protocol was successfully applied to the C-3 selective installation of a variety of aryl and vinyl groups on an isoquinolone scaffold. The C-2 selective alkenylation and arylation reactions of 4-quinolones were achieved by using a RhI-catalyzed decarbonylative coupling strategy to afford valuable C-2 functionalized 4-quinolones. The present method was compatible with a broad scope of substrates and applied to the C-3 selective functionalization of an isoquinolone scaffold. Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim1671sciescopu

Palladium-Catalyzed Divergent Arylation with Triazolopyridines: One-Pot Synthesis of 6-Aryl-2-alpha-styrylpyridines

We have developed a new strategy for palladium-catalyzed arylation reactions with triazolopyridines, wherein two different chemical transformations (C-3 vs. C-7) are observed by differentiating the substrates using different bases. The reactive palladium carbenoids were directly generated from triazolopyridines and underwent denitrogenative arylations with aryl bromides. Intriguingly, when potassium carbonate was replaced with potassium tert-butoxide, direct C-H arylation occurred at the most acidic position (C-7). Moreover, two different catalytic arylation events were successfully performed in a one-pot sequence, providing a convenient access to 6-aryl-2-alpha-styrylpyridines (c) 2016 Wiley-VCH Verlag GmbH&Co. KGaA, Wein1661sciescopu

Large-scale identification of human cerebrovascular proteins: Inter-tissue and intracerebral vascular protein diversity

<div><p>The human cerebrovascular system is responsible for regulating demand-dependent perfusion and maintaining the blood-brain barrier (BBB). In addition, defects in the human cerebrovasculature lead to stroke, intracerebral hemorrhage, vascular malformations, and vascular cognitive impairment. The objective of this study was to discover new proteins of the human cerebrovascular system using expression data from the Human Protein Atlas, a large-scale project which allows public access to immunohistochemical analysis of human tissues. We screened 20,158 proteins in the HPA and identified 346 expression patterns correlating to blood vessels in human brain. Independent experiments showed that 51/52 of these distributions could be experimentally replicated across different brain samples. Some proteins (40%) demonstrated endothelial cell (EC)-enriched expression, while others were expressed primarily in vascular smooth muscle cells (VSMC; 18%); 39% of these proteins were expressed in both cell types. Most brain EC markers were tissue oligospecific; that is, they were expressed in endothelia in an average of 4.8 out of 9 organs examined. Although most markers expressed in endothelial cells of the brain were present in all cerebral capillaries, a significant number (21%) were expressed only in a fraction of brain capillaries within each brain sample. Among proteins found in cerebral VSMC, virtually all were also expressed in peripheral VSMC and in non-vascular smooth muscle cells (SMC). Only one was potentially brain specific: VHL (Von Hippel-Lindau tumor suppressor). HRC (histidine rich calcium binding protein) and VHL were restricted to VSMC and not found in non-vascular tissues such as uterus or gut. In conclusion, we define a set of brain vascular proteins that could be relevant to understanding the unique physiology and pathophysiology of the human cerebrovasculature. This set of proteins defines inter-organ molecular differences in the vasculature and confirms the broad heterogeneity of vascular cells within the brain.</p></div

Proteins that show differences between VSMC and non-vascular SMC.

<p>Proteins that show differences between VSMC and non-vascular SMC.</p

Protein interaction networks among vascular proteins identified from the Human Protein Atlas.

<p>We applied the STRING tool (string-db.org; Version 10.0) to human brain EC proteins to identify possible novel networks among molecules. The graphical representation of proteins identified as having at least one connected partner in the EC protein set are presented here. Connections included both physical interactions, co-expression, and text-mined connected proteins, and only interactions that were consider medium to high confidence were included. The same analysis, applied to SMC proteins, yielded only limited protein interactions.</p

Proteins curated from the Human Protein Atlas that are expressed in both EC and VSMC of the brain.

<p>All proteins (n = 135) are predicted to be expressed in both types of the two principle types of vascular cells but not other cells of the central nervous system.</p